Northern Ireland Cancer Trials Network
Belfast Experimental Cancer Medicine Centre
TRIALS OPEN TO RECRUITMENT – February 2019
Please note that while we aim to update the NICTN clinical trials list on a monthly basis, the availability of clinical trials changes over this period. For the latest information we advise patients to discuss clinical trial availability with their own doctor.
THE NICTN OPEN CLINICAL TRIALS LIST
Bladder Cancer
RAIDER A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder
Bowel Cancer
NSCCG National Study Of Colorectal Cancer Genetics
BALLAD UK A trial to evaluate the potential benefit of adjuvant chemotherapy for small bowel adenocarcinoma
CReST 2 Colorectal Stenting Trial 2 – Uncovered and Covered Endoluminal Stenting in the acute management of obstructing colorectal cancer in the palliative setting
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
CHALLENGE A phase III study of the impact of a physical activity programme on disease-free survival in patients with high risk stage II or stage III colon cancer: A randomised controlled trial
Brain Tumours
ROAM Radiation Versus Observation Following Surgical Resection Of Atypical Meningioma: A Randomised Controlled Trial
Breast Cancer
POSNOC POsitive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes
Olympia A randomised, double-blind, parallel group, placebo-controlled multi-centre Phase III study to assess the efficacy and safety of olaparib versus placebo as adjuvant treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy
LORIS A Phase III Trial of Surgery versus Active Monitoring for Low Risk Ductal Carcinoma in Situ (DCIS)
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
OPTIMA Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
PIONEER Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer
ARCS-Multi Phase 1b multi-indication study of anetumab ravtansine (BAY 94-9343) in patients with mesothelin expressing advanced or recurrent malignancies (including triple negative breast cancer)
Cervical Cancer
INTERLACE A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with locally advanced cervical cancer
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Children’s Cancers (Royal Belfast Hospital for Sick Children)
UKALL 2011 United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011
IMPORT A SIOP Renal Tumours Study Group Prospective Clinical Study. Improving Population Outcomes for Renal Tumours of Childhood
EuroNet PHL-LP1 First international Inter-Group Study for nodular lymphocyte-predominant Hodgkin’s Lymphoma in Children and Adolescents
EURO Ewing 2012 International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours
rEECur International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma
FACT Factors Associated with Childhood Tumours Study
Ewings PK 2013 Study Pilot study to investigate the early prediction of toxicity following induction chemotherapy in Ewing’s sarcoma by blood-borne biomarkers and correlation with age-dependent pharmacokinetic variation
Myechild01 International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia – Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy
SIOP Ependymoma II An International clinical program for the diagnosis and treatment of children, adolescents and young adults with ependymoma
Relapse in UK Neuroblastoma Clinical and Biological factors associated with relapse and length of survival following relapse in UK neuroblastomas
LCH-IV International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis
Endometrial (womb) Cancer
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Head and Neck Cancer
iNATT The interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project
Ion Is ablative radioiodine necessary for low risk differentiated thyroid cancer
NIMRAD A randomised placebo-controlled trial of synchronous nimorazole versus radiotherapy alone in patients with locally advanced head and neck squamous cell carcinoma not suitable for synchronous chemotherapy or cetuximab
Haematological Cancers (see below)
Lung Cancer
Stratified Medicine Programme 2 Cancer Research UK Stratified Medicine Programme 2
National Lung Matrix Trial National Lung Matrix Trial: Multi-drug, genetic marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer
CORE A Randomised Trial Of Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) For Extracranial Oligometastases
ARCS-Multi Phase 1b multi-indication study of anetumab ravtansine (BAY 94-9343) in patients with mesothelin expressing advanced or recurrent malignancies (including NSCLC adenocarcinoma)
SYSTEMS-2 A Randomised Phase II Trial of Standard Versus Dose Escalated Radiotherapy in the Treatment of Pain in Malignant Pleural Mesothelioma
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomized phase III trial.
KEYNOTE-598 A Phase 3, Randomized, Double-Blind Study of Pembrolizumab plu sIpilimunab plus Placebo in Previously Untreated, Stage IV, Metastatic Non-small Cell lung Cancer Subjects Whose Tumors are PD-L1 Postive (TPS ≥ 50%)
CONFIRM (Checkpoint Blockade For Inhibition Of Relapsed Mesothelioma) A Phase III Double-Blind, Placebo Controlled Trial To Evaluate The Efficacy Of Nivolumab In Relapsed Mesothelioma
Oesophageal Cancer
OCCAMS Multicentre Study to determine Predictive and Prognostic Biomarkers and Therapeutic Targets for Oesophageal and Junctional Adenocarcinoma including whole genome sequencing
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
Neo-AEGIS (NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study): Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (Modified MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction
Ovarian Cancer
ROCkeTS Refining Ovarian Cancer Test Accuracy Scores: A test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer protocol
NICCC A Randomised Phase II Study Of Nintedanib (BIBF1120) Compared To Chemotherapy In Patients With Recurrent Clear Cell Carcinoma Of The Ovary Or Endometrium
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
OCTOVA Randomised Phase II Trial of olaparib, chemotherapy or olaparib and cediranib in patients with BRCA mutated platinum–resistant ovarian cancer
Pancreatic Cancer
PIONEER A Phase I Study of Olaparib in combination with Chemo-radiation in Locally Advanced Pancreatic Cancer
Prostate Cancer
Stampede Systemic Therapy in Advancing or Metastatic Prostate cancer – Evaluation of Drug Efficacy
UKGPC UK Genetics Prostate Cancer Study
TOPARP Phase II Trial of Olaparib in Patients with Advanced Castration Resistant Prostate Cancer
SPORT High-Risk Trial A Randomised Feasibility Study Evaluating Stereotactic Prostate Radio Therapy In High-Risk Localised Prostate Cancer With Or Without Elective Nodal Irradiation
Immune gene expression and tumour microenvironment in prostate cancer How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?
RE-AKT A Randomised Phase II Study Of Enzalutamide (MDV3100) In Combination With AZD5363 In Patients With Metastatic Castration-Resistant Prostate Cancer
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
ACE Proof of concept Phase I/II trial of the CXCR2 antagonist AZD5069, administered in combination with enzalutamide, in patients with metastatic castration resistant prostate cancer
CTC STOP Utilising Circulating Tumour Cell (CTC) Counts to Optimize Systemic Therapy of Metastatic Prostate Cancer: CTC-Stop Trial
TrueNTH Global Registry Prostate Cancer Outcomes
GAP 4 Intense Exercise For Survival Among Men with Metastatic Castrate-Resistant Prostate Cancer (Interval-MCRPC): A Multicentre, Randomised, Controlled III Study
Sarcoma
EURO Ewing 2012 International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours
Stomach/Gastro-oesophageal junction Cancer
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
Neo-AEGIS (NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study): Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (Modified MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction
ARCS-Multi Phase 1b multi-indication study of anetumab ravtansine (BAY 94-9343) in patients with mesothelin expressing advanced or recurrent malignancies (including gastric/gastroesophageal junction adenocarcinoma)
Vulval Cancer
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Studies not specific to one particular type of cancer
CaPP3 A randomised double blind dose non-inferiority trial of a daily dose of 600mg versus 300mg versus 100mg of enteric coated aspirin as a cancer preventive in carriers of a germline pathological mismatch repair gene defect, Lynch Syndrome. Project 3 in the Cancer Prevention Programme
EASI-SWITCH Early Switch to Oral Antibiotic Therapy in Patients with Low Risk Neutropenic Sepsis
CIBRAC Chemoprevention in BRCA1 Mutation Carriers – a Proof of Concept Study
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
A Phase I trial of LY3143921 hydrate in solid tumours A Cancer Research UK phase I trial of LY3143921 hydrate (a CDC7 inhibitor) given orally once daily in adult patients with advanced solid tumours
FAK-PD1 A Phase I/IIA Study to Assess Safety, Tolerability and Preliminary Activity of FAK (defactinib) and PD-1 (Pembrolizumab) Inhibition in Patients with Advanced Solid Malignancies
CORE A Randomised Trial Of Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) For Extracranial Oligometastases
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
ARCS-Multi Phase 1b multi-indication study of anetumab ravtansine (BAY 94-9343) in patients with mesothelin expressing advanced or recurrent malignancies
Haematological Clinical Trials
Leukaemia
LI-1 A Programme Of Development For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome
UKALL 14 A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia
FLAIR Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab
AML19 Adults with Acute Leukaemia or High Risk Myelodysplastic Syndrome
UKALL 2011 United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011
AML 18 A Trial For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome
Lymphoma
MaPLe Molecular Profiling for Lymphoma Study
UKALL 2011 United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Multiple Myeloma
Other Haematological
Expanded PNH Registry Paroxysmal Nocturnal Haemoglobinuria (PNH) Registry
TREATT Trial To Evaluate Tranexamic Acid Therapy In Thrombocytopenia. A Double Blind, Randomised Controlled Trial Evaluating The Safety And Efficacy Of Tranexamic Acid In Patients With Haematological Malignancies With Severe Thrombocytopeni
AML 18 A Trial For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome
Idopathic Cytopenia Improving diagnosis in idiopathic cytopenia using gene sequencing
