Northern Ireland Cancer Trials Network
Belfast Experimental Cancer Medicine Centre
TRIALS OPEN TO RECRUITMENT – May 2018
Please note that while we aim to update the NICTN clinical trials list on a monthly basis, the availability of clinical trials changes over this period. For the latest information we advise patients to discuss clinical trial availability with their own doctor.
THE NICTN OPEN CLINICAL TRIALS LIST
Bladder Cancer
RAIDER A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder
Bowel Cancer
NSCCG National Study Of Colorectal Cancer Genetics
MERCURY 2 Low Rectal Cancer Study
ARISTOTLE A phase III trial comparing standard versus novel CRT as pre-operative treatment for MRI defined locally advanced rectal cancer
BALLAD UK A trial to evaluate the potential benefit of adjuvant chemotherapy for small bowel adenocarcinoma
MErCuRIC1 A Phase I study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients
CReST 2 Colorectal Stenting Trial 2 – Uncovered and Covered Endoluminal Stenting in the acute management of obstructing colorectal cancer in the palliative setting
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
CHALLENGE A phase III study of the impact of a physical activity programme on disease-free survival in patients with high risk stage II or stage III colon cancer: A randomised controlled trial
Brain Tumours
ROAM Radiation Versus Observation Following Surgical Resection Of Atypical Meningioma: A Randomised Controlled Trial
Breast Cancer
POSNOC POsitive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes
Olympia A randomised, double-blind, parallel group, placebo-controlled multi-centre Phase III study to assess the efficacy and safety of olaparib versus placebo as adjuvant treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy
MAMMO-50 Mammographic surveillance in breast cancer patients aged 50 years or older (available in Antrim and Craigavon hospitals)
LORIS A Phase III Trial of Surgery versus Active Monitoring for Low Risk Ductal Carcinoma in Situ (DCIS)
FAST-Forward Lymphatic RT Sub-Study FAST-Forward Randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer (Note recruitment on hold 06.12.17)
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
OPTIMA Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
CORE A Randomised Trial Of Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) For Extracranial Oligometastases
FAST-Forward Lymphatic RT Sub-Study FAST-Forward Randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer
PIONEER Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer
Cervical Cancer
INTERLACE A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with locally advanced cervical cancer
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Children’s Cancers (Royal Belfast Hospital for Sick Children)
UKALL 2011 United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011
CNS GCT II Prospective Trial For The Diagnosis And Treatment Of Children, Adolescents and Young Adults With Intracranial Germ Cell Tumours
IMPORT A SIOP Renal Tumours Study Group Prospective Clinical Study. Improving Population Outcomes for Renal Tumours of Childhood
EuroNet PHL-LP1 First international Inter-Group Study for nodular lymphocyte-predominant Hodgkin’s Lymphoma in Children and Adolescents
EURO Ewing 2012 International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours
rEECur International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma
FACT Factors Associated with Childhood Tumours Study
Ewings PK 2013 Study Pilot study to investigate the early prediction of toxicity following induction chemotherapy in Ewing’s sarcoma by blood-borne biomarkers and correlation with age-dependent pharmacokinetic variation
Myechild01 International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia – Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy
SIOP Ependymoma II An International clinical program for the diagnosis and treatment of children, adolescents and young adults with ependymoma
Endometrial (womb) Cancer
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Head and Neck Cancer
iNATT The interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project
Ion Is ablative radioiodine necessary for low risk differentiated thyroid cancer
Haematological Cancers (see below)
Lung Cancer
Stratified Medicine Programme 2 Cancer Research UK Stratified Medicine Programme 2
National Lung Matrix Trial National Lung Matrix Trial: Multi-drug, genetic marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer
CORE A Randomised Trial Of Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) For Extracranial Oligometastases
Oesophageal Cancer
OCCAMS Multicentre Study to determine Predictive and Prognostic Biomarkers and Therapeutic Targets for Oesophageal and Junctional Adenocarcinoma including whole genome sequencing
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
Neo-AEGIS (NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study): Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (Modified MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction
Ovarian Cancer
ROCkeTS Refining Ovarian Cancer Test Accuracy Scores: A test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer protocol
NICCC A Randomised Phase II Study Of Nintedanib (BIBF1120) Compared To Chemotherapy In Patients With Recurrent Clear Cell Carcinoma Of The Ovary Or Endometrium
ORZORA An Open-Label, Single-Arm, Multicentre Study To Assess The Clinical Effectiveness And Safety Of Lynparza (Olaparib) Capsules Maintenance Monotherapy In Platinum Sensitive Relapsed BRCA Mutated Ovarian Cancer Patients Who Are In Complete Or Partial Response Following Platinum Based Chemotherapy
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Pancreatic Cancer
PIONEER A Phase I Study of Olaparib in combination with Chemo-radiation in Locally Advanced Pancreatic Cancer
Prostate Cancer
UKGPC UK Genetics Prostate Cancer Study
TOPARP Phase II Trial of Olaparib in Patients with Advanced Castration Resistant Prostate Cancer
ADRRAD Neo-adjuvant Androgen Deprivation Therapy, Pelvic Radiotherapy and RADium-223 for new presentation T1-4 N0/1 M1B adenocarcinoma of prostate
SPORT High-Risk Trial A Randomised Feasibility Study Evaluating Stereotactic Prostate Radio Therapy In High-Risk Localised Prostate Cancer With Or Without Elective Nodal Irradiation
Immune gene expression and tumour microenvironment in prostate cancer How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?
RE-AKT A Randomised Phase II Study Of Enzalutamide (MDV3100) In Combination With AZD5363 In Patients With Metastatic Castration-Resistant Prostate Cancer
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
CORE A Randomised Trial Of Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) For Extracranial Oligometastases
Sarcoma
EURO Ewing 2012 International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours
Stomach/Gastro-oesophageal junction Cancer
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
Neo-AEGIS (NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study): Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (Modified MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction
Studies not specific to one particular type of cancer
CaPP3 A randomised double blind dose non-inferiority trial of a daily dose of 600mg versus 300mg versus 100mg of enteric coated aspirin as a cancer preventive in carriers of a germline pathological mismatch repair gene defect, Lynch Syndrome. Project 3 in the Cancer Prevention Programme
EASI-SWITCH Early Switch to Oral Antibiotic Therapy in Patients with Low Risk Neutropenic Sepsis
CIBRAC Chemoprevention in BRCA1 Mutation Carriers – a Proof of Concept Study
SINCERE A single-centre, assessor blind, randomised pilot study to evaluate the safety, tolerability and acceptability of RB Lotion compared to standard-of-care for Radiation Induced Skin Reactions (RISR), in subjects undergoing palliative external beam Radiotherapy (RT)
ADD ASPIRIN A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours
A Phase I trial of LY3143921 hydrate in solid tumours A Cancer Research UK phase I trial of LY3143921 hydrate (a CDC7 inhibitor) given orally once daily in adult patients with advanced solid tumours
FAK-PD1 A Phase I/IIA Study to Assess Safety, Tolerability and Preliminary Activity of FAK (defactinib) and PD-1 (Pembrolizumab) Inhibition in Patients with Advanced Solid Malignancies
CORE A Randomised Trial Of Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) For Extracranial Oligometastases
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Haematological Clinical Trials
Leukaemia
LI-1 A Programme Of Development For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome
UKALL 14 A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia
FLAIR Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab
IcICLLe Assessment of the Mechanism of Action of Ibrutinib (PCI-32765) in B-cell Receptor Pathway Inhibition in Chronic Lymphocytic Leukaemia (CLL)
AML19 Adults with Acute Leukaemia or High Risk Myelodysplastic Syndrome
UKALL 2011 United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011
CALiBRe Assessment of the Mechanism of Action of idelalisib (CAL101) in B-cell Receptor Pathway Inhibition in CLL
Genomic and epigenetic analysis of AML and MDS
AML 18 A Trial For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome
Lymphoma
MaPLe Molecular Profiling for Lymphoma Study
ARROVEN Post-Authorisation Safety Study (PASS) MA25101: An Observational Cohort Study of the Safety of Brentuximab Vedotin in the Treatment of Relapsed or Refractory CD30+ Hodgkin Lymphoma and Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma
UKALL 2011 United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011
HORIZONS A cohort study to explore recovery of health and well-being in adults diagnosed with cancer
Multiple Myeloma
C16021 A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study of Oral Ixazomib Maintenance Therapy After Initial Therapy in Patients With Newly Diagnosed Multiple Myeloma Not Treated With Stem Cell Transplantation
Other Haematological
Expanded PNH Registry Paroxysmal Nocturnal Haemoglobinuria (PNH) Registry
MEASURES The Myeloproliferative Neoplasms Quality of Life (MPN-QOL) International Study Group
ELASTIC A phase Ib study of Eltrombopag and Azacitidine in patients with high risk myelodysplastic syndomes and related disorders
TREATT Trial To Evaluate Tranexamic Acid Therapy In Thrombocytopenia. A Double Blind, Randomised Controlled Trial Evaluating The Safety And Efficacy Of Tranexamic Acid In Patients With Haematological Malignancies With Severe Thrombocytopeni
TAMARIN Effects of TAMoxifen on the Mutant Allele Burden And Disease Course In Patients With Myeloproliferative Neoplasms
Genomic and epigenetic analysis of AML and MDS
AML 18 A Trial For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome
Idopathic Cytopenia Improving diagnosis in idiopathic cytopenia using gene sequencing
ENABLE-NGS Enabling diagnosis in chronic B-cell lymphoproliferative disorders using Next-Generation Sequencing
