Belfast City Hospital

Trial A Phase I trial of LY3143921 hydrate in solid tumours
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A Cancer Research UK phase I trial of LY3143921 hydrate (a CDC7 inhibitor) given orally once daily in adult patients with advanced solid tumours

Trial ACE
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Proof of concept Phase I/II trial of the CXCR2 antagonist AZD5069, administered in combination with enzalutamide, in patients with metastatic castration resistant prostate cancer

Trial Add-Aspirin Trial
Cancer Type Bowel Cancer, Breast Cancer, Oesophageal Cancer, Prostate Cancer, Stomach Cancer, and Non-specific
Hospital(s) Belfast City Hospital and Craigavon Hospital
Information

A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours

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Trial AML 18
Cancer Type Haematological Cancers, Leukaemia, and Other Haematological
Hospital(s) Belfast City Hospital
Information

AML 18 A Trial For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome

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Trial AML19
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

Adults with Acute Leukaemia or High Risk Myelodysplastic Syndrome

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Trial ARCS-Multi
Cancer Type Breast Cancer, Lung Cancer, Stomach Cancer, and Non-specific
Hospital(s) Belfast City Hospital
Information

Phase 1b multi-indication study of anetumab ravtansine (BAY 94-9343) in patients with mesothelin expressing advanced or recurrent malignancies

Trial BALLAD UK
Cancer Type Bowel Cancer
Hospital(s) Belfast City Hospital
Information

A trial to evaluate the potential benefit of adjuvant chemotherapy for small bowel adenocarcinoma

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Trial CaPP3
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A randomised double blind dose non-inferiority trial of a daily dose of 600mg versus 300mg versus 100mg of enteric coated aspirin as a cancer preventive in carriers of a germline pathological mismatch repair gene defect, Lynch Syndrome. Project 3 in the Cancer Prevention Programme

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Trial CHALLENGE
Cancer Type Bowel Cancer
Hospital(s) Belfast City Hospital
Information

A phase III study of the impact of a physical activity programme on disease-free survival in patients with high risk stage II or stage III colon cancer: A randomised controlled trial

Trial CIBRAC
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Chemoprevention in BRCA1 Mutation Carriers – a Proof of Concept Study

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Trial CORE
Cancer Type Breast Cancer, Lung Cancer, Prostate Cancer, and Non-specific
Hospital(s) Belfast City Hospital
Information

A Randomised Trial Of Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) For Extracranial Oligometastases

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Trial CTC STOP
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Utilising Circulating Tumour Cell (CTC) Counts to Optimize Systemic Therapy of Metastatic Prostate Cancer: CTC-Stop Trial

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Trial EASI-SWITCH
Cancer Type Non-specific
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Ulster Hospital
Information

Early Switch to Oral Antibiotic Therapy in Patients with Low Risk Neutropenic Sepsis

Trial EURO Ewing 2012
Cancer Type Children’s Cancer and Sarcoma
Hospital(s) Belfast City Hospital and Royal Belfast Hospital for Sick Children
Information

International Randomised Controlled Trial
for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours

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Trial Expanded PNH Registry
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Paroxysmal Nocturnal Haemoglobinuria (PNH) Registry

Trial FAK-PD1
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A Phase I/IIA Study to Assess Safety, Tolerability and Preliminary Activity of FAK (defactinib) and PD-1 (Pembrolizumab) Inhibition in Patients with Advanced Solid Malignancies

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Trial FLAIR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
Information

Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab

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Trial Idopathic Cytopenia
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Improving diagnosis in idiopathic cytopenia using gene sequencing

Trial Immune gene expression and tumour microenvironment in prostate cancer
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?

Trial iNATT
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

The interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project

Trial INTERLACE
Cancer Type Cervical Cancer
Hospital(s) Belfast City Hospital
Information

A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with locally advanced cervical cancer

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Trial Ion
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

Is ablative radioiodine necessary for low risk differentiated thyroid cancer

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Trial LI-1
Cancer Type Haematological Cancers
Hospital(s) Belfast City Hospital
Information

A Programme Of Development For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome

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Trial LORIS
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital and Ulster Hospital
Information

A phase III trial of surgery versus active monitoring for low risk Ductal Carcinoma in Situ (DCIS)

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Trial MaPLe
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Antrim Hospital, Belfast City Hospital, and Ulster Hospital
Information

Molecular Profiling for Lymphoma Study

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Trial National Lung Matrix Trial
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

National Lung Matrix Trial: Multi-drug, genetic marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer

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Trial Neo-AEGIS
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study: Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (Modified MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction

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Trial NICCC
Cancer Type Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Study Of Nintedanib (BIBF1120) Compared To Chemotherapy In Patients With Recurrent Clear Cell Carcinoma Of The Ovary Or Endometrium

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Trial NIMRAD
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

A randomised placebo-controlled trial of synchronous nimorazole versus radiotherapy alone in patients with locally advanced head and neck squamous cell carcinoma not suitable for synchronous chemotherapy or cetuximab

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Trial NSCCG
Cancer Type Bowel Cancer
Hospital(s) Antrim Hospital, Belfast City Hospital, and Ulster Hospital
Information

National Study Of Colorectal Cancer Genetics

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Trial OCCAMS
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

Multicentre Study to determine Predictive and Prognostic Biomarkers and Therapeutic Targets for Oesophageal and Junctional Adenocarcinoma including whole genome sequencing

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Trial OCTOVA
Cancer Type Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Randomised Phase II Trial of olaparib, chemotherapy or olaparib and cediranib in patients with BRCA mutated platinum–resistant ovarian cancer

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Trial Olympia
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

A randomised, double-blind, parallel group, placebo-controlled multi-centre Phase III study to assess the efficacy and safety of olaparib versus placebo as adjuvant treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy

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Trial OPTIMA
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital and Ulster Hospital
Information

Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis

Trial PIONEER
Cancer Type Pancreatic Cancer
Hospital(s) Belfast City Hospital
Information

A Phase I Study of Olaparib in combination with Chemo-radiation in Locally Advanced Pancreatic Cancer

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Trial PIONEER (Breast cancer)
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer

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Trial POSNOC
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

POsitive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes

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Trial RAIDER
Cancer Type Bladder Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder

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Trial RE-AKT
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Study Of Enzalutamide (MDV3100) In Combination With AZD5363 In Patients With Metastatic Castration-Resistant Prostate Cancer

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Trial ROAM
Cancer Type Brain Tumour
Hospital(s) Belfast City Hospital
Information

Radiation versus Observation Following Surgical Resection Of Atypical Meningioma: A Randomised Controlled Trial

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Trial ROCkeTS
Cancer Type Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Refining Ovarian Cancer Test Accuracy Scores: A test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer protocol

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Trial SARON
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial.

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Trial SPORT High-Risk Trial
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Feasibility Study Evaluating Stereotactic Prostate Radio Therapy In High-Risk Localised Prostate Cancer With Or Without Elective Nodal Irradiation

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Trial SRA737-01
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A phase 1/2 trial of SRA737 (A Chk1 Inhibitor) Administered Orally in Subjects with Advanced Cancer

Trial Stampede
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Systemic Therapy in Advancing or Metastatic Prostate cancer – Evaluation of Drug Efficacy

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Trial Stratified Medicine Programme 2
Cancer Type Lung Cancer
Hospital(s) Antrim Hospital, Belfast City Hospital, Craigavon Hospital, and Ulster Hospital
Information

Cancer Research UK Stratified Medicine Programme 2

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Trial SYSTEMS-2
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Trial of Standard Versus Dose Escalated Radiotherapy in the Treatment of Pain in Malignant Pleural Mesothelioma

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Trial TOPARP
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Phase II Trial of Olaparib in Patients with Advanced Castration Resistant Prostate Cancer

Trial TREATT
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Trial To Evaluate Tranexamic Acid Therapy In Thrombocytopenia. A Double Blind, Randomised Controlled Trial Evaluating The Safety And Efficacy Of Tranexamic Acid In Patients With Haematological Malignancies With Severe Thrombocytopenia

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Trial TrueNTH Global Registry - Prostate Cancer Outcomes
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

TrueNTH Global Registry – Prostate Cancer Outcomes

Trial UKALL 14
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia

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Trial UKALL 2011
Cancer Type Children’s Cancer, Haematological Cancers, Leukaemia, and Lymphoma
Hospital(s) Belfast City Hospital and Royal Belfast Hospital for Sick Children
Information

United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011

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Trial UKGPC
Cancer Type Prostate Cancer
Hospital(s) Altnagelvin Hospital, Antrim Hospital, Belfast City Hospital, and Ulster Hospital
Information

UK Genetics Prostate Cancer Study

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