Belfast City Hospital

Trial A Phase I trial of LY3143921 hydrate in solid tumours
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A Cancer Research UK phase I trial of LY3143921 hydrate (a CDC7 inhibitor) given orally once daily in adult patients with advanced solid tumours

Trial ACE
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Proof of concept Phase I/II trial of the CXCR2 antagonist AZD5069, administered in combination with enzalutamide, in patients with metastatic castration resistant prostate cancer

Trial Add-Aspirin Trial
Cancer Type Bowel Cancer, Breast Cancer, Oesophageal Cancer, Prostate Cancer, Stomach Cancer, and Non-specific
Hospital(s) Antrim Hospital, Belfast City Hospital, and Craigavon Hospital
Information

A Phase III, Double-Blind, Placebo-Controlled Randomised Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival after Primary Therapy in Common Non-Metastatic Solid Tumours

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Trial ADSCAN
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-Small Cell Lung Cancer

Trial ALLEGRO
Cancer Type Bowel Cancer
Hospital(s) Belfast City Hospital
Information

A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery

Trial AML 18
Cancer Type Haematological Cancers, Leukaemia, and Other Haematological
Hospital(s) Belfast City Hospital
Information

AML 18 A Trial For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome

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Trial AML19
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

Adults with Acute Leukaemia or High Risk Myelodysplastic Syndrome

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Trial ARCS-Multi
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Phase 1b multi-indication study of anetumab ravtansine (BAY 94-9343) in patients with mesothelin expressing advanced or recurrent malignancies (including triple negative breast cancer)

Trial BALLAD UK
Cancer Type Bowel Cancer
Hospital(s) Belfast City Hospital
Information

A trial to evaluate the potential benefit of adjuvant chemotherapy for small bowel adenocarcinoma

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Trial CaPP3
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A randomised double blind dose non-inferiority trial of a daily dose of 600mg versus 300mg versus 100mg of enteric coated aspirin as a cancer preventive in carriers of a germline pathological mismatch repair gene defect, Lynch Syndrome. Project 3 in the Cancer Prevention Programme

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Trial CellCentric
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CellCentric CCS1477-01
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced solid/metastatic tumours

Trial CHALLENGE
Cancer Type Bowel Cancer
Hospital(s) Belfast City Hospital
Information

A phase III study of the impact of a physical activity programme on disease-free survival in patients with high risk stage II or stage III colon cancer: A randomised controlled trial

Trial CIBRAC
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Chemoprevention in BRCA1 Mutation Carriers – a Proof of Concept Study

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Trial CONFIRM (Checkpoint Blockade For Inhibition Of Relapsed Mesothelioma)
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Phase III Double-Blind, Placebo Controlled Trial To Evaluate The Efficacy Of Nivolumab In Relapsed Mesothelioma

Trial DANTE
Cancer Type Melanoma
Hospital(s) Belfast City Hospital
Information

A randomised phase III trial to evaluate the Duration of ANti-PD1 monoclonal antibody Treatment in patients with metastatic mElanoma

Trial EASI-SWITCH
Cancer Type Non-specific
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Ulster Hospital
Information

Early Switch to Oral Antibiotic Therapy in Patients with Low Risk Neutropenic Sepsis

Trial ENABLE-NGS
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Enabling diagnosis in chronic B-cell lymphoproliferative disorders using Next-Generation Sequencing

Trial ENRICH
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Belfast City Hospital
Information

A randomised, open label study of rituximab + ibrutinib (IR) vs rituximab + chemotherapy (R-Chemo) in older patients with untreated mantle cell lymphoma. Primary objective is to assess whether IR is superior to R-Chemo in terms of progression-free survival (PFS)

Trial Expanded PNH Registry
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Paroxysmal Nocturnal Haemoglobinuria (PNH) Registry

Trial FAK-PD1
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A Phase I/IIA Study to Assess Safety, Tolerability and Preliminary Activity of FAK (defactinib) and PD-1 (Pembrolizumab) Inhibition in Patients with Advanced Solid Malignancies

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Trial FLAIR
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Altnagelvin Hospital, Belfast City Hospital, and Craigavon Hospital
Information

Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab

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Trial FOCUS 4
Cancer Type Bowel Cancer
Hospital(s) Belfast City Hospital
Information

Molecular Selection Of Therapy In Colorectal Cancer: A Molecularly-Stratified Randomised Controlled Trials Programme

Trial GAP 4
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Intense Exercise For Survival Among Men With Metastatic Castrate-Resistant Prostate Cancer (Interval-MCRPC): A Multicentre, Randomised, Controlled Phase III Study

Trial HALT
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

Targeted therapy with or without dose intensified radiotherapy for oligo-progressive disease in oncogene-addicted lung tumours

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Trial ICHOR
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

Investigation of Circulating Haematological Biomarkers in Cancer

Trial Idiopathic Cytopenia
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Improving diagnosis in idiopathic cytopenia using gene sequencing

Trial IMAT Neuroblastoma
Cancer Type Children’s Cancer
Hospital(s) Belfast City Hospital and Royal Belfast Hospital for Sick Children
Information

A randomised phase I/II study of Intensity Modulated Arc Therapy techniques in abdominal neuroblastoma

Trial Immune gene expression and tumour microenvironment in prostate cancer
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

How does radiotherapy affect immune gene expression and the tumour microenvironment in men with localised prostate cancer?

Trial iNATT
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

The interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project

Trial INTERIM
Cancer Type Melanoma
Hospital(s) Belfast City Hospital
Information

A randomised phase II feasibility study of INTERmittent versus continuous dosing or oral targeted combination therapy In patients with BRAFV600 mutant stage 3 unresectable or metastatic Melanoma

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Trial INTERLACE
Cancer Type Cervical Cancer
Hospital(s) Belfast City Hospital
Information

A phase III multicentre trial of weekly induction chemotherapy followed by standard chemoradiation versus standard chemoradiation alone in patients with locally advanced cervical cancer

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Trial INTERVAL (GAP 4)
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Intense Exercise for Survival Among Men With Metastatic Castrate-Resistant Prostate Cancer (INTERVAL – MCRPC): A Multicenter, Randomised, Controlled, Phase III Study

Trial Ion
Cancer Type Head & Neck Cancer
Hospital(s) Belfast City Hospital
Information

Is ablative radioiodine necessary for low risk differentiated thyroid cancer

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Trial KEYNOTE-598
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Phase 3, Randomized, Double-Blind Study of Pembrolizumab plus Ipilimumab vs Pembrolizumab plus Placebo in Previously Untreated, Stage IV, Metastatic Non-small Cell Lung Cancer Subjects Whose Tumors are PD-L1 Positive (TPS ≥ 50%)

Trial LI-1
Cancer Type Haematological Cancers
Hospital(s) Belfast City Hospital
Information

A Programme Of Development For Older Patients With Acute Myeloid Leukaemia And High Risk Myelodysplastic Syndrome

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Trial LORIS
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital and Ulster Hospital
Information

A phase III trial of surgery versus active monitoring for low risk Ductal Carcinoma in Situ (DCIS)

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Trial Manifest
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

A Phase 1/2 Study of CPI-0610, a Small Molecule Inhibitor of BET
Proteins: Phase 1 (Dose Escalation of CPI-0610 in Patients with Haematological Malignancies) and Phase 2 (Dose Expansion of CPI-0610 with and without Ruxolitinib in Patients with Myelofibrosis)

Trial MaPLe
Cancer Type Haematological Cancers and Lymphoma
Hospital(s) Antrim Hospital, Belfast City Hospital, and Ulster Hospital
Information

Molecular Profiling for Lymphoma Study

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Trial National Lung Matrix Trial
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

National Lung Matrix Trial: Multi-drug, genetic marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer

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Trial Neo-AEGIS
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study: Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (Modified MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction

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Trial NSCCG
Cancer Type Bowel Cancer
Hospital(s) Antrim Hospital, Belfast City Hospital, and Ulster Hospital
Information

National Study Of Colorectal Cancer Genetics

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Trial NuTide:301
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A TWO-PART, PHASE I OPEN LABEL, DOSE ESCALATION AND EXPANSION STUDY TO ASSESS SAFETY, PHARMACOKINETICS AND CLINICAL ACTIVITY OF NUC-3373, A NUCLEOTIDE ANALOGUE, IN PARTICIPANTS WITH ADVANCED SOLID TUMOURS

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Trial NuTide:301
Cancer Type Non-specific
Hospital(s) Belfast City Hospital
Information

A two-part, phase 1 open label, dose escalation and expansion study to assess safety, pharmacokinetics and clinical activity of nuc-3373, a nucleotide analogue, in participants with advanced solid tumours

Trial OCCAMS
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

Multicentre Study to determine Predictive and Prognostic Biomarkers and Therapeutic Targets for Oesophageal and Junctional Adenocarcinoma including whole genome sequencing

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Trial OCTOVA
Cancer Type Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Randomised Phase II Trial of olaparib, chemotherapy or olaparib and cediranib in patients with BRCA mutated platinum–resistant ovarian cancer

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Trial PIONEER
Cancer Type Pancreatic Cancer
Hospital(s) Belfast City Hospital
Information

A Phase I Study of Olaparib in combination with Chemo-radiation in Locally Advanced Pancreatic Cancer

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Trial PIONEER (Breast cancer)
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer

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Trial PLATFORM
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

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Trial PLATFORM
Cancer Type Oesophageal Cancer and Stomach Cancer
Hospital(s) Belfast City Hospital
Information

PLAnning Treatment For Oesophago-Gastric Cancer: a Randomised Maintenance Therapy Trial

Trial POSNOC
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

POsitive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes

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Trial PRIMETIME
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers (PRIMETIME)

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Trial PROFILES
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

bnP for pRediction of Outcome FollowIng Lung rEsection Surgery

Trial RAIDER
Cancer Type Bladder Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder

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Trial RE-AKT
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Study Of Enzalutamide (MDV3100) In Combination With AZD5363 In Patients With Metastatic Castration-Resistant Prostate Cancer

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Trial ROAM
Cancer Type Brain Tumour
Hospital(s) Belfast City Hospital
Information

Radiation versus Observation Following Surgical Resection Of Atypical Meningioma: A Randomised Controlled Trial

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Trial ROCkeTS
Cancer Type Ovarian Cancer
Hospital(s) Belfast City Hospital
Information

Refining Ovarian Cancer Test Accuracy Scores: A test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer protocol

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Trial ROSCO
Cancer Type Breast Cancer
Hospital(s) Belfast City Hospital
Information

Response To Optimal Selection Of Neo-Adjuvant Chemotherapy In Operable Breast Cancer

Trial SARON
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial.

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Trial SCOPE 2
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with
oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients
with a poor early response using positron emission tomography (PET)

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Trial SCOPE 2
Cancer Type Oesophageal Cancer
Hospital(s) Belfast City Hospital
Information

A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET)

Trial SELF-MANAGEMENT ONLINE SHOULDER EXERCISES AFTER BREAST CANCER SURGERY
Cancer Type Breast Cancer
Hospital(s) Antrim Hospital, Belfast City Hospital, Craigavon Hospital, and Ulster Hospital
Information

Designing, developing and testing a web-based tailored intervention for self-management exercising to enable optimal shoulder and arm outcomes after surgery for breast cancer

Trial Stampede
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

Systemic Therapy in Advancing or Metastatic Prostate cancer – Evaluation of Drug Efficacy

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Trial Stratified Medicine Programme 2
Cancer Type Lung Cancer
Hospital(s) Antrim Hospital, Belfast City Hospital, Craigavon Hospital, and Ulster Hospital
Information

Cancer Research UK Stratified Medicine Programme 2

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Trial SYSTEMS-2
Cancer Type Lung Cancer
Hospital(s) Belfast City Hospital
Information

A Randomised Phase II Trial of Standard Versus Dose Escalated Radiotherapy in the Treatment of Pain in Malignant Pleural Mesothelioma

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Trial TREATT
Cancer Type Haematological Cancers and Other Haematological
Hospital(s) Belfast City Hospital
Information

Trial To Evaluate Tranexamic Acid Therapy In Thrombocytopenia. A Double Blind, Randomised Controlled Trial Evaluating The Safety And Efficacy Of Tranexamic Acid In Patients With Haematological Malignancies With Severe Thrombocytopenia

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Trial TrueNTH Global Registry - Prostate Cancer Outcomes
Cancer Type Prostate Cancer
Hospital(s) Belfast City Hospital
Information

TrueNTH Global Registry – Prostate Cancer Outcomes

Trial UKALL 14
Cancer Type Haematological Cancers and Leukaemia
Hospital(s) Belfast City Hospital
Information

A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia

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Trial UKALL 2011
Cancer Type Children’s Cancer, Haematological Cancers, Leukaemia, and Lymphoma
Hospital(s) Belfast City Hospital and Royal Belfast Hospital for Sick Children
Information

United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011

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Trial UKGPC
Cancer Type Prostate Cancer
Hospital(s) Altnagelvin Hospital, Antrim Hospital, Belfast City Hospital, and Ulster Hospital
Information

UK Genetics Prostate Cancer Study

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